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Main disadvantages of nucleos(t)ide analogues are the long duration of treatment and the risk of developing resistance.
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However, only three of 10 interpretation systems showed significant independent prediction of the 12- or 24-week response in a multivariable model that included characteristics of patient history, baseline features such as HIV-1 RNA levels and number of resistance mutations, and characteristics of the salvage regimen (number of new and total number of antiretroviral drugs and use of a new drug class).
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At any time that exposed persons test positive for HCV RNA, the clinician should refer for medical management and possible treatment by a clinician with experience in treating HCV.
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